Composite guar gum-silver nanoparticle hydrogels as self-healing, injectable, and antibacterial biomaterials

C Talodthaisong; W Boonta; S Thammawithan; R Patramanon; N Kamonsutthipaijit; JA Hutchison; S Kulchat

Journal article

Composite guar gum-silver nanoparticle hydrogels as self-healing, injectable, and antibacterial biomaterials

C Talodthaisong, W Boonta, S Thammawithan, R Patramanon, N Kamonsutthipaijit, JA Hutchison, S Kulchat

Materials Today Communications | ELSEVIER | Published : 2020

DOI: 10.1016/j.mtcomm.2020.100992

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Abstract

Biomaterial-based hydrogels incorporating antibacterial agents may provide sustainable solutions to biomedical device failures and the prevention of infections. Herein we report guar gum hydrogels, cross-linked with borax and loaded with silver nanoparticles, that are injectable, exhibit rapid self-healing, and show antibacterial properties towards both gram-positive and gram-negative bacteria. The hydrogels are fully characterized by infrared spectroscopy, thermogravimetric analysis, scanning electron microscopy, and rheological measurements. An important focus was to minimize borax content, thus reducing the toxicity of the gels greatly, whilst retaining their favorable viscoelastic proper..

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University of Melbourne Researchers

James Hutchison Author

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Awarded by Australian Research Council

Funding Acknowledgements

C.T. was supported by The Science Achievement Scholarship of Thailand (SAST). W.B. was supported by Development and Promotion of Science and Technology Talents Project (DPST).S.K. thanks the financial and laboratories support from Faculty of Science, Khon Kaen University, Research and Technology Transfer Affairs (KKUSyn60_003),and the Center of Excellence for Innovation in Chemistry (PERCH-CIC), Ministry of Higher Education, Science, Research and Innovation. We also thank Dr. Supagorn Rugmai, Dr. Siriwat Soontaranon and Chonthicha Kaewhan at the beamline BL1.3 W:SAXS, Synchrotron Light Research Institute (Public Organization, Nakhon Ratchasima) for helpful discussion and setup. J. A. H. acknowledges support from Australian Research Council (ARC) DECRA award (DE130101300), a Future Fellowship (FT180100295), and the Centre of Excellence in Exciton Science (CE170100026). We acknowledge Assoc. Prof. Dr. Sayan Saengsuwan and Ubon Ratchathani University for viscosities with fruitful discussion. Finally, we also thank Asst. Prof. Dr. Ghislaine Vantomme (Eindhoven University of Technology, Netherland) and Assoc. Prof. Dr. Sittipong Amnuaypanich (Khon Kaen University, Thailand) for discussions on rheology investigation.